These are the questions I'm wrestling with at the moment, as I work through another revise and resubmit, AKA, the bane of academic research life. In this case, I have been extremely fortunate, with very positive comments. That's no guarantee, of course, but I have learned some thing along the way about carefully listening to reviewer comments. In fact, my strategy now is not only to prepare exact quotes from each of the reviewers' points made, but to also rewrite those comments so that I can make sure that I understand them, a task which I can accomplish in several stages, which over time gets me closer to understanding.
Burham's plan for Chicago (wikipedia)